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    Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion. Target: Others Sodium Picosulfate displays cytotoxic effects on cultured liver cells. 800 and 1600 mg/mL induces dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver cells of ...

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    Sep 01, 2020· Description: Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion. In vitro: Sodium Picosulfate displays cytotoxic effects on cultured liver cells. 800 and 1600 mg/mL induces dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values of the rapidly growing cultured liver ...

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    Inhibition of intestinal microflora beta-glucuronidase modifies the distribution of the active metabolite of the antitumor agent, irinotecan hydrochloride (CPT-11) in rats.[Pubmed:9744772] Cancer Chemother Pharmacol. 1998;42(4):280-6.

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